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KMID : 0370219740180040243
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Yakhak Hoeji
1974 Volume.18 No. 4 p.243 ~ p.248
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Synthesis of Mannich Base of Benzoxazolin-2-thione and Alkyl Ester of PAS and Their Antimicrobial Activities
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정원근/Chung WK
정상헌/정필근/윤원영/이남복/Chung SH/Chung PK/Yoon WY/Lee NB
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Abstract
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Nine benzoxazolin-2-thione derivatives were synthesized as the potential antimicrobial substances. These compounds were tested for the antimicrobial activities using Staphylococcus aureus and Escherichia coli by way of tube dilution method. The three compounds of 1, II and VII inhibited the growth of S. aureus at the concentration of 1mcg/ml, and III, VI, VIII and IX exhibited considerable antimicrobial activities against S. aureus at the concentration of l0mcg/ml. As to the growth of E. Coli, VII VII and VIII inhibited at the concentration of 1mcg/ml. II,III and IV exhibited considerable antimicrobial activities against E. coli at the concentration of 10mcg/ml.
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